Interactions between pyruvate carboxylase and other mitochondrial enzymes.
نویسندگان
چکیده
منابع مشابه
Inhibitors of Pyruvate Carboxylase.
This review aims to discuss the varied types of inhibitors of biotin-dependent carboxylases, with an emphasis on the inhibitors of pyruvate carboxylase. Some of these inhibitors are physiologically relevant, in that they provide ways of regulating the cellular activities of the enzymes e.g. aspartate and prohibitin inhibition of pyruvate carboxylase. Most of the inhibitors that will be discusse...
متن کاملMetabolic analysis of Escherichia coli in the presence and absence of the carboxylating enzymes phosphoenolpyruvate carboxylase and pyruvate carboxylase.
Fermentation patterns of Escherichia coli with and without the phosphoenolpyruvate carboxylase (PPC) and pyruvate carboxylase (PYC) enzymes were compared under anaerobic conditions with glucose as a carbon source. Time profiles of glucose and fermentation product concentrations were determined and used to calculate metabolic fluxes through central carbon pathways during exponential cell growth....
متن کاملPyruvate Carboxylase from Chicken Liver
On the basis of initial velocity and product inhibition studies a nonclassical Ping Pong Bi Bi Uni Uni mechanism has been proposed for pyruvate carboxylase from chicken liver. The nonclassical feature of this mechanism is the proposal that each active site on the enzyme is composed of two separate and functionally distinct catalytic sites, i.e., a separate catalytic site exists for the reactant...
متن کاملPyruvate Carboxylase INHIBITION OF THE MAMMALIAN AND AVIAN LIVER ENZYMES BY a-KETOGLUTARATE
Various intermediates of the tricarboxylic acid cycle and related compounds have been examined as inhibitors of pyruvate carboxylase purified from chicken and rat liver. These studies have indicated that cr-ketoglutarate is a specific inhibitor of chicken liver pyruvate carboxylase. Addition of cu-ketoglutarate causes the apparent KA for acetyl coenzyme A to become less favorable but does not a...
متن کاملProperties and function of yeast pyruvate carboxylase.
Cannata and Stoppani (1, 2) found that bakers’ yeast contains an adenosine diphosphate-dependent phosphoenolpyruvate carboxykinase, and they ascribed the essential physiological role of oxaloacetate synthesis to it. Doubts concerning their interpretation arose, however, when it was revealed (3, 4) that cellfree preparations of the same microorganism could catalyze the direct carboxylation of py...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1993
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)46795-0